Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
作者： Walaa salah Elserwy , Neama A Mohamed , Emad M. M. Kassem , M. M Mounier , Khaled Mahmoud
关键词:
摘要: Different acid chlorides (2a-d) reacted with anthranilic to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material synthesize some condensed and non-condensed heterocyclic compounds by reaction nitrogen nucleophiles e.g., hydrazine hydrate, formamide. Some of the newly synthesized analogues were chosen evaluate their cytotoxic activity against human carcinoma cell lines (HePG2- MCF7- A549). The docking results revealed that nearly all containing N-phenyl aniline showed significant inhibition for three lines.
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