Oestrogen receptors and antagonism of steroid hormone action.

摘要: NON-STEROIDAL anti-oestrogens antagonise the effects of oestrogen on uterine growth, vaginal cornification and ovulation1, their mechanism action has been suggested to reside in ability compete for cytoplasmic binding sites, or receptors, thereby reducing formation receptor complexes2–4. Since these complexes target tissues, with subsequent translocation nuclear is considered primary event action5,6, reduction number would lead decreased physiological responses oestrogen. This implies that antagonist complex should have a lower intrinsic biological activity than oestradiol complex; is, stimulate oestrogenic be less complex. Based assumptions, antagonism observed after single injection antagonists; we now found this not case. Thus, non-steroidal could acting as antagonists by competing initially receptors.