Defeating pathogen drug resistance: guidance from evolutionary theory.

摘要: Many of the greatest challenges in medicine and public health involve evolution drug resistance by pathogens. Recent advances theory natural selection suggest that there are two broad classes pathogen traits can be targeted drugs or vaccines. The first class, consisting benefit individual organisms bearing them, causes a strong evolutionary response rapid emergence resistance. second groups including provider, weaker less Although most previous development has it would advantageous to focus on class as targets for vaccine development. Specific examples test cases discussed.