摘要: Before the development of a clinically useful form insulin, prognosis for insulin-dependent diabetes patients was grim. When young woman with condition became pregnant, she and her offspring rarely survived pregnancy. With short-term survival more likely to occur. We then had dubious privilege observing long-term complications disabilities that accompany long duration (1). The large number diabetic individuals followed at Joslin Clinic has been source much information concerning problems encountered in pregnancy by these patients. White reported 50% all pregnant women institution between January 1936 1965 vascular lesions, 10% them “malignant angiopathy.” rate spontaneous abortions high, mothers often experienced severe hypoglycemic episodes during Specifically, 2,000 cases obstetrical found proliferative retinopathic changes 87 cases. Of 20 eyes sustained hemorrhage, 11 progressed blindness. Viable infants resulted from 74% (2). Cassar colleagues 20% 67 retinopathy, lesions (3). Similarly, Jervell et al progression retinopathy 68 234 who were through Rikshospitalet Oslo (4).