In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development
作者： Keith Hoffmaster , Kim Brouwer , Dietrich Keppler , Daniel Bow , Yaofeng Cheng
DOI: 10.1038/CLPT.2013.81
关键词:
摘要: This white paper addresses current approaches and knowledge gaps concerning methods to assess the role of transport proteins in drug/metabolite disposition humans. The discussion focuses on vitro tools address key questions drug development, including vesicle- cell-based systems. How these can be used liability compounds for transporter-based drug-drug interactions (DDIs) vivo is also explored. Existing challenges examine involvement transporters are discussed.
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