Tooth germ invagination from cell–cell interaction: Working hypothesis on mechanical instability

摘要: In the early stage of tooth germ development, bud dental epithelium is invaginated by underlying mesenchyme, resulting in formation a cap-like folded shape. This bud-to-cap transition plays critical role determining steric design tooth. The epithelial-mesenchymal interaction within essential for mediating transition. Here, we present theoretical model to describe autonomous process morphological transition, which introduce mechanical interactions among cells. Based on our observations, assumed that peripheral cells bound tightly each other form an elastic sheet, and mesenchymal covered would restrict its growth. By considering time-dependent growth cells, were able numerically show buckled spontaneously, reminiscent cap-stage form. difference rates between interior parts epithelium, together with size germ, factors number invaginations. Our results provide new hypothesis explain histological features germ.