Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess

摘要: The interplay between vitamin D and the growth hormone (GH)/insulin-like factor (IGF)-I system is very complex to date it not fully understood. GH directly regulates renal 1 alpha-hydroxylase activity, although action of in modulating metabolism may also be IGF-I mediated. On other hand, increases circulating deficiency should normalized before measurement concentrations obtain reliable unbiased values. Indeed, linear after treatment nutritional seems mediated through activation GH/IGF-I axis suggests an important role as a link proliferating cartilage cells plate secretion. Vitamin levels are commonly lower patients with (GHD) than controls, variable prevalence insufficiency or deficiency, this condition worsen already known cardiovascular metabolic risk GHD, finding common all studies. In addition, data on impact GHD quite conflicting. Conversely, active acromegaly, characterized by chronic excess, both increased decreased have been highlighted, becomes even more complicated when we consider acromegaly treatment, medical surgical. current review summarizes available main disorders axis, providing overview state art.