Transportation of drug–gold nanocomposites by actinomyosin motor system
作者： Harsimran Kaur , Archana Chaudhary , Inderpreet Kaur , Kashmir Singh , Lalit M. Bharadwaj
DOI: 10.1007/S11051-010-9987-1
关键词:
摘要: Nanotechnology is playing an important role in drug delivery to overcome limitations of conventional systems terms solubility, vivo stability, pharmacokinetics, and bio-distribution. The controlled transportation into the cell within a major challenge be addressed. Cellular molecular motors have been exploited for their cargo carrying capacity various applications including engineering health care. Combination nanotechnology biomolecular can address some challenges delivery. In present study, nanocomposites has demonstrated. Nanocomposites 6-mercaptopurine levodopa drugs (cancer Parkinson’s disease, respectively) were prepared with gold nanoparticles (GNPs) by covalent attachment these attached actin filaments. These in-turn transported filaments on myosin tracks. Characterization formation was done UV–Vis spectroscopy, field emission scanning electron microscopy, transmission confocal microscopy. GNP composites formed sulfide amide bond formation, respectively. Average velocity filament found 3.17 3.89 μm/s 6-mercaptopurine, respectively, as compared 4.0–6.0 μm/s. Three concepts proposed study based polycationic complex interaction cellular Biomolecular Adaptor Retrograde Transport (BART) technology. aspects this heads toward development approach utilize nanoscale endogenously.
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