The role of carbohydrate as a post-translational modification of the receptor for epidermal growth factor.

摘要: The receptor for EGF is an integral membrane protein that mediates the mitogenic response of target cells to and EGF-like polypeptides (1). has been purified from cultured human tumor (2,3) mouse liver (4). a glycoprotein having estimated molecular mass approximately 170,000 daltons no subunit structure. In addition N-linked oligosaccharide chains, also modified post-translationally by phosphate on serine, threonine, tyrosine residues extensive disulfide bond arrangement predicted. molecule’s ligand binding capacity, acts as allosteric enzyme; it contains tyrosine-specific kinase activity activated (5,6). However, substrates this receptor-kinase are physiologically relevant mito-genesis have not yet identified. focus article will be glycosylation during biosynthesis molecule.