Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α -glucosidase inhibitors

摘要: Based on the previous reports α-glucosidase inhibitory activity of benzimidazole class, we intend to evaluate further this class as potential inhibitors enzyme. Thus, in current study synthesis 5-bromo-2-aryl derivatives 1–25 was carried out. All synthetic compounds were characterized by different spectroscopic techniques EIMS, HRMS, 1H-NMR, and 13C-NMR. Molecular docking also performed selected 1, 4, 7, 17 having varying substitution pattern order understand molecular interaction molecules with active site evaluated for their vitro activities. Twenty-three out twenty-five showed excellent moderate range IC50 = 12.4–103.2 μM. Inhibitory results compared standard drug acarbose (IC50 38.25 ± 0.12 μM). Compounds 1 37.82 0.08 μM), 9 37.76 0.05 12 24.96 0.09 16 21.15 μM) 8.34 0.02 inhibition Especially, found be five-fold more than standard.