Cannabinoid receptor 1 gene is associated with alcohol dependence.
作者： Miguel Marcos , Isabel Pastor , Cristina de la Calle , Laura Barrio-Real , Francisco-Javier Laso
DOI: 10.1111/J.1530-0277.2011.01623.X
关键词:
摘要: Background: Alcohol dependence (AD) vulnerability is determined by a complex array of genetic factors. Given the potential role endocannabinoid system in AD, polymorphisms within cannabinoid receptor 1 gene (CNR1) have been potentially associated with susceptibility to this disease. We thus aimed examine relationship between 3 allelic variants CNR1 (rs6454674, rs1049353, and rs806368) AD. Methods: Genotyping aforementioned was carried out PCR 298 male alcoholics (187 them AD) 155 healthy controls. Single-marker, haplotype, interaction analysis were performed analyze influence on AD susceptibility. Results: found an association after haplotype analysis. Alcoholic patients TGT (corresponding rs6454674-rs1049353-rs806368 order) less prone (p = 0.017). Besides, G/T substitution first marker (GGT haplotype) or C/T third (TGC more likely develop (p = 0.006 0.004, respectively) G allele rs6454674 single nucleotide polymorphism (SNP) C rs806368 SNP (p = 0.009). Conclusions: Our findings support previously reported associations alcohol other substances emphasizes relevance AD.
sci-hub.se 参考文章(31)
Basalingappa L. Hungund, Istvan Szakall, Agota Adam, Balapal S. Basavarajappa, Csaba Vadasz, Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens Journal of Neurochemistry. ,vol. 84, pp. 698- 704 ,(2003) , 10.1046/J.1471-4159.2003.01576.X
Ildiko Racz, Andras Bilkei-Gorzo, Zsuzsanna E. Toth, Kerstin Michel, Miklós Palkovits, Andreas Zimmer, A Critical Role for the Cannabinoid CB1 Receptors in Alcohol Dependence and Stress-Stimulated Ethanol Drinking The Journal of Neuroscience. ,vol. 23, pp. 2453- 2458 ,(2003) , 10.1523/JNEUROSCI.23-06-02453.2003
M Herkenham, AB Lynn, MR Johnson, LS Melvin, BR de Costa, KC Rice, Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study The Journal of Neuroscience. ,vol. 11, pp. 563- 583 ,(1991) , 10.1523/JNEUROSCI.11-02-00563.1991
Amine Benyamina, Oussama Kebir, Lisa Blecha, Michel Reynaud, Marie-Odile Krebs, CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta‐analysis Addiction Biology. ,vol. 16, pp. 1- 6 ,(2011) , 10.1111/J.1369-1600.2009.00198.X
U. W. Preuss, G. Koller, P. Zill, B. Bondy, M. Soyka, Alcoholism-related phenotypes and genetic variants of the CB1 receptor. European Archives of Psychiatry and Clinical Neuroscience. ,vol. 253, pp. 275- 280 ,(2003) , 10.1007/S00406-003-0440-7
William D. Dupont, Walton D. Plummer, Power and Sample Size Calculations for Studies Involving Linear Regression Controlled Clinical Trials. ,vol. 19, pp. 589- 601 ,(1998) , 10.1016/S0197-2456(98)00037-3
Danielle M. Dick, Laura J. Bierut, The genetics of alcohol dependence Current Psychiatry Reports. ,vol. 8, pp. 151- 157 ,(2006) , 10.1007/S11920-006-0015-1
Lutz G Schmidt, Jerzy Samochowiec, Ulrich Finckh, Ewa Fiszer-Piosik, Jan Horodnicki, B Wendel, Hans Rommelspacher, Margret R Hoehe, Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Drug and Alcohol Dependence. ,vol. 65, pp. 221- 224 ,(2002) , 10.1016/S0376-8716(01)00164-8
Benjamin M. Neale, Pak C. Sham, The future of association studies: gene-based analysis and replication. American Journal of Human Genetics. ,vol. 75, pp. 353- 362 ,(2004) , 10.1086/423901
BASALINGAPPA L. HUNGUND, BALAPAL S. BASAVARAJAPPA, Role of Endocannabinoids and Cannabinoid CB1 Receptors in Alcohol‐Related Behaviors Annals of the New York Academy of Sciences. ,vol. 1025, pp. 515- 527 ,(2004) , 10.1196/ANNALS.1316.064