Synaptic and photoreceptor components in retinal pigment epithelial cell transplanted retinas of royal college of surgeons dystrophic rats
作者： H. J. Sheedlo , L. Li , C. J. Barnstable , J. E. Turner
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摘要: Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In adult RPE-cell 4 month-old RCS rats, HNK-1, a marker for carbohydrate the neural adhesion molecule (N-CAM), was detected immunocytochemically inner outer plexiform layers ganglion bodies their axons. HNK-1 also nontreated but reduced to scattered patches layer. addition, immunoreactivity SVP-38 antibody recognizing synaptophysin found both rat RPE-transplanted rats. Furthermore, segments immunostained opsin RET-P1 However, only debris material detected. These results strongly suggest that RPE transplants not rescue maintain an essential functional capacity, this case, layers. © 1993 Wiley-Liss, Inc.
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