Structural and functional analysis of domains of the progesterone receptor
作者： Krista K. Hill , Sarah C. Roemer , Mair E.A. Churchill , Dean P. Edwards
DOI: 10.1016/J.MCE.2011.07.017
关键词:
摘要: Steroid hormone receptors are multi-domain proteins composed of conserved well-structured regions, such as ligand (LBD) and DNA binding domains (DBD), plus other naturally unstructured regions including the amino-terminal domain (NTD) hinge region between LBD DBD. The is more than just a flexible DBD capable co-regulatory minor groove flanking response elements. Because can directly participate in it has also been termed carboxyl terminal extension (CTE) domain. CTE NTD dynamic receptor that adopt multiple conformations depending on environment interacting DNA. Both have important regulatory roles for functions related to ability form active conformations. This review focuses studies progesterone (PR), well work with steroid/nuclear receptors.
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