A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.
作者： M.E. Meyer , C Quirin-Stricker , T Lerouge , M.T. Bocquel , H Gronemeyer
DOI: 10.1016/S0021-9258(19)50100-4
关键词: Transcription (biology) 、 DNA-binding domain 、 Biology 、 Promoter 、 Steroid hormone 、 Cell 、 Gene isoform 、 Molecular biology 、 Amino acid 、 Progesterone receptor
摘要: The two transcription activation functions (TAFs) of the human progesterone receptor (hPR) have been characterized. TAF-1, located in N-terminal region A/B, has narrowed down to a 91-amino acid sequence, which is sufficient for chimeras with GAL4 DNA binding domain. Both hPR TAF-1 and TAF-2 activate minimal promoter yeast. No autonomous TAF could be found 164 amino acids (designated AB3) are responsible differential promoters by isoforms A B. Reduction target gene complexity did not alter this activation, indicating that AB3 does require additional promoter-bound factors exert its effect. Instead, cell specificity ability squelch hPR-induced suggest isoform activity due effect limiting factor binds AB3.
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