Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections

摘要: Abstract Although hippocampal involvement in amyotrophic lateral sclerosis (ALS) has been consistently highlighted by postmortem studies, memory impairment remains under-recognized and the of specific subfields their connectivity patterns are poorly characterized in vivo. A prospective multimodal neuroimaging study undertaken with 50 well-characterized ALS patients, 18 patients Alzheimer's disease, 40 healthy controls to evaluate mesial temporal lobe profile. Patients disease have divergent signatures. The cornu ammonis 2/3 subfield hippocampus-amygdala transition area most affected regions contrast where presubiculum subiculum vulnerable regions. Tractography reveals considerable fornix perforant pathway pathology both patient groups. Mesial structures a selective disease-specific vulnerability profiles, white matter projections exhibit concomitant degeneration. Our combined gray analyses indicate connectivity-based, network-defined interconnected as opposed contiguous adjacent structures. findings underline importance screening for deficits personalized management strategies ALS.