Synthesis and structural elucidation of biliary excreted thioether derivatives of mitoxantrone
作者： K. Mewes , J. Blanz , S. Freund , G. Ehninger , K.-P Zeller
DOI: 10.3109/00498259409043232
关键词:
摘要: 1. Hplc-MS coupling has been used for the identification of thioether derivatives anticancer agent mitoxantrone in bile pig.2. Three biologically relevant new have synthesized by a horseradish peroxidase-catalysed reaction.3. The characterized means ionspray tandem mass spectrometry and nmr including two-dimensional techniques.4. carbon-sulphur bond formation takes place at hydroquinone moiety anthraquinone skeleton pointing to importance tautomeric equilibrium between different species oxidized drug.5. occurrence compounds biological systems suggests metabolic pathway that may be cytotoxicity (oxidative activation).
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