Interaction of the peroxidase-derived metabolite of mitoxantrone with nucleic acids. Evidence for covalent binding of 14C-labeled drug.
作者： Krzysztof reszka , John A. Hartley , Pawel Kolodziejczyk , J.William Lown
DOI: 10.1016/0006-2952(89)90523-6
关键词:
摘要: The antitumor agent mitoxantrone undergoes horseradish peroxidase-catalyzed oxidation by hydrogen peroxide to an identifiable cyclic metabolite which is a substituted hexahydronaphtho[2,3-f]-quinoxaline-7,12-dione. Binding of DNA inhibited enzymatic the drug. mitoxantrone, derived from action HRP/H2O2 system on drug, bound non-covalently oligomers. Spectrophotometric analyses such complexes showed formation new, blue-shifted, metachromatic absorption band was observed when base pair drug ratio close 1. Measurements unwinding angles suggest that metabolite, in contrast did not intercalate but rather externally DNA. Experiments with 14C-labeled confirmed peroxidase-activated binds covalently
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