Neurogenic Hypertension in the Rat

摘要: Several techniques of radical denervation the sino-aortic depressor areas were tried in order to produce a permanent neurogenic hypertension rat. The aortic fibers interrupted at neck level by resecting nerves which usually exhibit baroreceptor activity, namely, isolated nerve, sympathetic, and laryngeal nerves. carotid sinus was denervated stripping bifurcation painting with phenol. When resected bilaterally, one-stage operation, all rats showed symptoms cerebral ischemia, dying shortly thereafter. Isolated baroreceptors followed transitory hypertension. No changes preasure observed when only sinuses denervated. A few usual pathways interrupted, except superior developed chronic Yet, obtain consistently it necessary include every route. simple operation for complete is described. This procedure used 140 that then studied periods up one year. All operated animals presented some degree Blood pressure measurements made during first week even hypertensive. observation suggests rat no latent period appearance present. Hypertension 75% year; blood returned normal values remaining 25%, after third month. Extirpation adrenal medulla had effect on evolution rats. measured repeatedly unanesthetized tail plethysmography. Pressure determined this method, though 10 20 mm Hg lower, approximated mean arterial recorded directly from femoral artery normotensive hypertensive included an increase systolic as well diastolic pressure. heart rates quiet within range and, general, close correlation between increases elevations rate. Normal have marked fluctuations both rate walking or stimulated; these much greater animals. Moreover, large oscillations synchronous respiratory movements particularly latter slower deeper than normal. seemed tolerate very well. Histological examination tissues myocardial hypertrophy thickening basement membrane glomerular capsule. severity abnormality closely associated duration