Plasma triglycerides related decrease in high-density lipoprotein cholesterol and its association with myocardial infarction in heterozygous familial hypercholesterolemia.

摘要: Recent studies suggest that decreased levels of high-density liopoprotein (HDL) may contribute to the risk premature occlusive atherosclerosis in familial hypercholesterolemia (FH). To investigate further, we have analyzed concentration as well distribution HDL cholesterol relation plasma triglycerides and their influence on ischaemic heart disease FH subjects. The study was carried out 71 men with heterozygous 46 matched controls. subjects were relatively young a mean age 38 ± 11 years. Tendon xanthomatas observed 57% subjects, whereas ischemic identified 33%. Compared normals, value is significantly reduced by 21% heterozygotes (42 12 v 33 9 mg/dL, P < 0.001). decrease highly correlated (r = −0.50, 0.001) VLDL −0.53, Moreover, not associated elevated LDL −0.20, NS), which primary characteristic feature However, weakly related total −0.24, 0.05). body weight also contributory reduction −0.42, 0.01), probably due its strong positive correlation +0.54, Grouping basis triglyceride less than 200 mg/dL (IIa phenotype) more (IIb shows undergoes further significant latter group (36 30 Since level similar both groups (314 68 316 76 results an increased LDL/HDL ratio IIb phenotypes. Although normally distributed controls type IIa phenotypes, skewed lower values IIb. In addition cholesterol, presence tendon equally (51.1% 62.5%, respectively). Similarly, incidence angina pectoris (19.2% 12.5% IIb, respectively) approximately same groups. differences are striking myocardial infarction (MI), three-fold (25% 8.5%) compared IIa. These findings indicate excess, deficiency contributes severity disease, revealed from manifestation MI some heterozygotes.