Anatomy and function of the orbital frontal cortex, II: Function and relevance to obsessive-compulsive disorder.

摘要: The authors review neurophysiological, neurobehavioral, and neuropsychological investigations of the orbital frontal cortex (OFC) in human non-human primates. article critically examines role OFC 1) recognition reinforcers; 2) stimulus-reinforcer learning; 3) modulation responses based on changes reinforcement contingencies; 4) emotions, social behavior, autonomic regulation; 5) mnemonic functions; 6) rule learning. Examining these functional areas with reference to OFC's anatomical neurophysiological properties, suggest ways which might contribute obsessive-compulsive disorder.