[38] Experimental glomerulonephritis

摘要: Publisher Summary This chapter discusses the analysis of experimental glomerulonephritis. There exist several animal models that closely resemble various forms human The resemblance includes, in most instances, morphological, immunohistological, and pathophysiological similarities. also describes different methods for producing studying three cover spectrum fixed planted antigens mediator systems. Mediators glomerular injury induced by such immune deposits vary widely models. They include complement (C) system acting either through its terminal, membranolytic pathway or via inflammatory action leukocytes; antibody-directed influx antibody alone. Host species, nature dose antibody, distribution antigen influence which mediators will operate studied to date. redistribution epithelial cell follows binding; subsequent shedding resulting complexes is thought account observed subepithelial electron densities.