Regulation of pulsatile luteinizing hormone secretion in experimental uremia.
作者： QIHAN DONG , DAVID J. HANDELSMAN
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摘要: Previous studies have shown that male rats with experimental uremia manifest profound suppression of circulating LH and testosterone levels, yet, paradoxically, after castration gonadotropin levels are elevated greatly above those nonuremic castrate control rats. To investigate further this phenomenon, we characterized pulsatile secretion in uremia. Mature orchidectomized Wistar subtotal nephrectomy demonstrated a 43% reduction pulse frequency, but 157% increase amplitude 335% mean compared sham-operated controls. All parameters were highly correlated plasma creatinine (r = 0.53-0.75). determine the mechanism increased amplitude, tested responsiveness postcastration uremic pituitary to exogenous GnRH (0.01-10 micrograms/kg) Latin square design. Plasma response was linearly related logarithm dose rats, markedly We conclude causes decreased frequency independent testicular feedback. Pituitary hypersensitivity magnifies thereby is major factor causing paradoxical hyperelevation castration.
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