Changes in the hypothalamic-pituitary-gonadal axis in men after cadaver kidney transplantation and cyclosporine therapy.

摘要: A variety of plasma androgens, estradiol, follicle-stimulating hormone, luteinizing prolactin, cortisol, and thyroid parameters were examined in 10 men followed serially before after cadaver kidney transplantation. Before transplantation, testosterone levels below normal 8 the men. Free testosterone, hormone at lower range values, yet estradiol elevated 3-fold, prolactin also high. One month all hormones measured suppressed, probably reflecting high-dose steroids multiple-drug regimens used period following operation. After 3 months, when other immunosuppressants reduced cyclosporine dosage was stabilized, restored toward normal. 12 exceeded pretransplant levels. Plasma dramatically decreased transplantation remained thereafter. These data indicate that abnormalities observed patients with end-stage renal disease are Androgen suppressed immediately to succeeding months despite chronic usage cyclosporine, suggesting currently doses, does not prevent restoration hypothalamic-pituitary-testicular axis.