Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients.
作者： Jia Zhou , Tong Ding , Weidong Pan , Ling-yan Zhu , Lian Li
DOI: 10.1002/IJC.24556
关键词:
摘要: Immunosuppression mediated by regulatory T cells (Tregs) is a key facilitator of tumor immune evasion, but the source of these Tregs and their contribution to human cancer …
sci-hub.se 参考文章(39)
Jeffrey W. Pollard, Tumour-educated macrophages promote tumour progression and metastasis Nature Reviews Cancer. ,vol. 4, pp. 71- 78 ,(2004) , 10.1038/NRC1256
Hervé Groux, Anne O'Garra, Mike Bigler, Matthieu Rouleau, Svetlana Antonenko, Jan E. de Vries, Maria Grazia Roncarolo, A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature. ,vol. 389, pp. 737- 742 ,(1997) , 10.1038/39614
Dong-Ming Kuang, Qiyi Zhao, Jing Xu, Jing-Ping Yun, Changyou Wu, Limin Zheng, Tumor-Educated Tolerogenic Dendritic Cells Induce CD3ε Down-Regulation and Apoptosis of T Cells through Oxygen-Dependent Pathways Journal of Immunology. ,vol. 181, pp. 3089- 3098 ,(2008) , 10.4049/JIMMUNOL.181.5.3089
Ilona Kryczek, Shuang Wei, Linhua Zou, Gefeng Zhu, Peter Mottram, Huanbin Xu, Lieping Chen, Weiping Zou, Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells Journal of Immunology. ,vol. 177, pp. 40- 44 ,(2006) , 10.4049/JIMMUNOL.177.1.40
Karsten Mahnke, Kurt Schönfeld, Sabine Fondel, Sabine Ring, Svetlana Karakhanova, Katharina Wiedemeyer, Tanja Bedke, Theron Scott Johnson, Volker Storn, Sonja Schallenberg, Alexander Herrmann Enk, Depletion of CD4+CD25+ human regulatory T cells in vivo: Kinetics of Treg depletion and alterations in immune functions in vivo and in vitro International Journal of Cancer. ,vol. 120, pp. 2723- 2733 ,(2007) , 10.1002/IJC.22617
François Ghiringhelli, Cedric Menard, Pierre Emmanuel Puig, Sylvain Ladoire, Stephan Roux, François Martin, Eric Solary, Axel Le Cesne, Laurence Zitvogel, Bruno Chauffert, Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients Cancer Immunology, Immunotherapy. ,vol. 56, pp. 641- 648 ,(2007) , 10.1007/S00262-006-0225-8
Weiping Zou, Immunosuppressive networks in the tumour environment and their therapeutic relevance Nature Reviews Cancer. ,vol. 5, pp. 263- 274 ,(2005) , 10.1038/NRC1586
Junliang Fu, Dongping Xu, Zhenwen Liu, Ming Shi, Ping Zhao, Baoyun Fu, Zheng Zhang, Huiyin Yang, Hui Zhang, Chunbao Zhou, Jinxia Yao, Lei Jin, Huifen Wang, Yongping Yang, Yang-Xing Fu, Fu-Sheng Wang, Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology. ,vol. 132, pp. 2328- 2339 ,(2007) , 10.1053/J.GASTRO.2007.03.102
Koji Kono, Hiromichi Kawaida, Akihiro Takahashi, Hidemitsu Sugai, Kosaku Mimura, Naoto Miyagawa, Hideo Omata, Hideki Fujii, CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunology, Immunotherapy. ,vol. 55, pp. 1064- 1071 ,(2006) , 10.1007/S00262-005-0092-8
Weiyun Z. Ai, Jing-Zhou Hou, Robert Zeiser, Debra Czerwinski, Robert S. Negrin, Ronald Levy, Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells International Journal of Cancer. ,vol. 124, pp. 239- 244 ,(2009) , 10.1002/IJC.23881