Solubility modelling and thermodynamic aspect of d-aspartic acid in aqueous co-solvent mixtures of N-methyl-2-pyrrolidone, N,N-dimethylformamide, dimethyl sulfoxide and 1.4-dioxane
作者： Xi Zhao , Ali Farajtabar , Hongkun Zhao , Gui Han
DOI: 10.1016/J.JCT.2019.06.025
关键词:
摘要: Abstract The solubility of d -aspartic acid in co-solvent mixtures dimethyl sulfoxide (DMSO) (1) + water (2), N , -dimethylformamide (DMF) -methyl-2-pyrrolidone (NMP) (2) and 1,4-dioxane at the temperatures from (288.15/298.15 to 333.15) K was reported. Experiments were performed through saturation shake-flask technique. maximum values observed neat DMF (DMSO, NMP 1,4-dioxane) for four aqueous mixtures. Through Jouyban-Acree model, well correlated attaining RAD less than 2.55% RMSD 2.81 × 10 −4 . local mole fractions DMSO (DMF, or water nearby analyzed Inverse Kirkwood–Buff integrals method. -Aspartic preferentially solvated by water-rich compositions; while within intermediate co-solvent-rich compositions, (NMP 1,4-dioxane) + water In addition, model Kamlet Taft linear solvation energy relationships employed order rationalize co-solvency effect identify its main components. It found that work needed breaking solvent-solvent interactions presented cavity term mainly controlled enhancement over entire composition range all binary
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