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DOI: 10.1017/CBO9780511489136.009
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摘要: Ordinary coalface knowledge This book has followed two high-profile examples of pharmacogenetics, unpacking assumptions, beliefs and contexts along the way. I have shown both how to, not get an example personalised medicine into clinical practice, explored messy intersection between industry, health service funders clinicians. chapter draws together ideas around pharmacogenetics by returning to three dichotomies introduced in 1: coalface–expectations, knowledge–resistance ordinary–revolutionary technology. Having just ordinariness Herceptin, it is this dichotomy that first turn. In case studies, pharmacogenetic tests do arise out nowhere, but rather, they are enmeshed their technical, social ethical context can only be understood those terms. Whatever claims commentators, APOE testing for Alzheimer's does raise some same issues as ‘ordinary’ susceptibility gene testing. And however revolutionary Herceptin seems when discussed on financial pages, once enters clinic becomes ordinary cancer treatment, subject institutional stresses strains, with clinicians' attitudes towards understating shaped experience other, older treatments, Tamoxifen. If, arrive, better thought ordinary, opposed revolutionary, then should alert us importance within which such used.