Neuroendocrine Changes in Alzheimer’s Disease: Raised Plasma Concentrations of Growth Hormone and Thyroid Stimulating Hormone and Reduced Concentrations of Oestrogen-Stimulated Neurophysin
作者： J. E. Christie , L. J. Whalley , J. Bennie , H. Dick , D. H. R. Blackwood
DOI: 10.1007/978-1-4684-5131-3_39
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摘要: The neuropathological (Ishii, 1965) and some of the neurochemical features Alzheimer-type dementia (ATD) affect not only cerebral cortex but also subcortical structures including hypothalamus in which there are reductions concentrations acetylcholine (Davies, 1979), noradrenaline (Yates et al, 1981) somatostatin (Davies 1982). Somatostatin is reduced CSF patients with ATD (Wood Acetylcholine, involved control secretion pituitary hormones (Reichlin, 1985) aim present study was to determine whether plasma hormone would 1) reflect changes central neurotransmitters that occur ATD, 2) prove useful differential diagnosis from other causes depression.
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