Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample.

摘要: Experimental models suggest that increased aldosterone and sodium intake are associated with renovascular damage resultant proteinuria. We hypothesized serum urinary would be albumin excretion, an indicator of kidney damage. evaluated 2700 participants (53% women, mean age 58 years) from the Framingham Offspring Study who attended a routine examination between 1995 1998, were free heart failure renal failure, underwent testing for aldosterone, spot sodium, excretion (urine albumin/creatinine ratio, UACR), latter two indexed to creatinine. Stepwise multivariable linear regression was used evaluate relations UACR index aldosterone. In regression, log positively log-UACR ( P -value trend across quintiles