Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy

摘要: We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall survival were inferior to those reported prolonged modeled on pediatric protocols. Survival superior receiving allogeneic BMT compared chemopurged autologous transplant or maintenance (patients ineligible declining BMT). In multivariate analysis, non-L2-FAB, higher ara-C dose, absence CNS disease, non-Ph1+ karyotype, BMT, T cell phenotype, younger age associated improved survival. Autologous was not chemotherapy, appears unlikely provide adequate curative treatment most ALL if followed by maintenance.