An analysis of the periodicity of conserved residues in sequence alignments of G-protein coupled receptors
作者： D. Donnelly , M.S. Johnson , T.L. Blundell , J. Saunders
DOI: 10.1016/0014-5793(89)81438-3
关键词:
摘要: Twenty-three sequences from the family of G-protein coupled receptors have been aligned according to 'historical alignment' procedure Feng and Doolittle. Fourier transform analysis this reveals that parts five seven putative membrane-spanning regions exhibit a periodicity conserved/nonconserved residues which is compatible with alpha-helix. This would place conserved on one side helix, may face inside proposed membered helical bundle.
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