Efficacy of diltiazem for control of symptoms of coronary arterial spasm

摘要: Abstract To evaluate the efficacy of calcium antagonist diltiazem for therapy active coronary arterial spasm, 13 patients with clinical variant angina attributed to documented spasm completed a prospective randomized double-blind crossover trial (120 and 240 mg/ day) versus placebo. Response was assessed diary technique measuring frequency angina, consumption nitroglycerin percent pain-free days. When 120 mg diltiazem/day compared paired placebo period there significant increase in days (from 43 71 [p = 0.03]), but no decrease (p 0.06) or 0.32). 50 79 0.03]) both 1.6 0.4 episodes/day 1.3 0.4/day 0.01]). Diltiazem found be highly effective drug control symptoms without side effects excellent patient tolerance.