Vesicle deposition and subsequent membrane–melittin interactions on different substrates: A QCM-D experiment

摘要: Abstract Quartz crystal microbalance with dissipation (QCM-D) technique is one of the most effective methods to monitor dynamic behaviors a layer on solid surface. Moreover, it has been reported recently that able provide fingerprint for peptide–membrane interactions. In this work, QCM-D combined computer simulations was employed investigate deposition and transformation vesicles, as well subsequent membrane–melittin interactions different substrates. A range substrate surfaces, i.e. naked SiO 2 without or Au/polyelectrolyte coating, were produced. The nature determined whether adsorbed vesicles present high-quality supported bilayer an assembled vesicle matrix, which consequently influenced It indicated by related lipid packing state membrane key factor determine mechanism membrane–peptide Furthermore, work might be good example application exploration membrane-active peptides.