Molecular Response and Cooperative Behavior during the Interactions of Melittin with a Membrane: Dissipative Quartz Crystal Microbalance Experiments and Simulations

作者: Naiyan Lu , Kai Yang , Bing Yuan , Yuqiang Ma

DOI: 10.1021/JP305141R

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摘要: The molecular-level interactions of an antimicrobial peptide melittin with supported membrane were studied by the combination dissipative quartz crystal microbalance (QCM-D) experiments and computer simulations. We found response behavior lipids upon adsorption greatly influence their interactions. perturbance reorientation lipid in liquid phase facilitate insertion a trans-membrane way, but solid phase, asymmetrical disruption happens. Apart from state, local peptide-to-lipid ratio also affects capacity melittin. When number density is high, adjacent peptides can cooperatively penetrate into membrane. This observation explains occurrence conventional “carpet” mechanism.

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