Spontaneous Conversion and Maintenance of Sinus Rhythm by Amiodarone in Patients With Heart Failure and Atrial Fibrillation Observations from the Veterans Affairs Congestive Heart Failure Survival Trial of Antiarrhythmic Therapy (CHF-STAT)
作者： Prakash C Deedwania , Bramah N Singh , Kenneth Ellenbogen , Susan Fisher , Ross Fletcher
DOI: 10.1161/01.CIR.98.23.2574
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摘要: Background—In a multicenter, double-blind, placebo-controlled study, the long-term effects of amiodarone on morbidity and mortality in patients with congestive heart failure (CHF) atrial fibrillation (AF) were evaluated during 4-year period. Methods Results—Of 667 CHF, 103 (15%) had AF at baseline. Of these, 51 randomized to 52 placebo. The group sinus rhythm comparable except for higher proportion nonischemic versus ischemic cardiomyopathy (41% 27%, P<0.005). mean ventricular response (VR) over 24 hours was reduced by 2 weeks (20%, P=0.001), 6 months (18%, 12 (16%, P=0.006). Maximal VR 22% (P=0.001) weeks, 19% months, 14% months. Sixteen 4 placebo converted study (χ2=9.23, P=0.002). During follow-up, 11 268 si...
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