Maternal nutritional manipulations program adipose tissue dysfunction in offspring.

摘要: Based on the concept of Developmental Origin Health and Disease, both human animal studies have demonstrated a close link between nutrient supply perturbations in fetus or neonate (i.e., maternal undernutrition, obesity, gestational diabetes and/or rapid catch-up growth) increased risk adult-onset obesity. Indeed, adipose tissue has been recognized as key target developmental programming sex-and depot-specific manner. Despite different time windows, similar mechanisms described rodents bigger mammals (sheep, primates). Maternal nutritional manipulations reprogram offspring's resulting series alterations: enhanced adipogenesis lipogenesis, impaired sympathetic activity with reduced noradrenergic innervations thermogenesis well low-grade inflammation. These changes affect development, distribution composition predisposing offspring to fat accumulation. Modifications hormonal sensitivity leptin, insulin, glucocorticoids) epigenetic leading persistent gene expression may account for long-lasting across generations.