Tumor markers in evaluating the response to radiotherapy in unresectable pancreatic cancer

摘要: Background/aims Serum carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic (CEA) are useful tumor markers in the diagnosis of pancreatic cancer. However, little research has shown their value for evaluating response to radiotherapy patients with advanced Methodology Serial changes serum CA levels were studied 34 unresectable All had a level 100 U/ml or greater before treatment received as an initial treatment. A responder was defined patient whose reduced by more than 50% pre-treatment after We investigated relationship between survival. also serial CEA 20 5 ng/ml radiotherapy, Results observed seven (21%) four (20%) patients, respectively. Median survival times responders non-responders 318 122 days, respectively, median 281 151 Based on results Cox regression analysis, relative rates cancer death 0.24 (95% confidence interval, 0.08 0.72) analysis 0.19 0.04 0.84) analysis. Conclusion may be assessing effectiveness Further investigations necessary determine CEA.