LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia.

摘要: We have cloned and characterized a mouse cDNA coding for LFB3, DNA binding protein containing an extra-large homeodomain. The first 315 amino acids of LFB3 are highly homologous to the domain LFB1, regulatory involved in expression several liver-specific genes. is transcriptional activator which binds as dimer forms heterodimers with LFB1 both vitro vivo. However, seems not be directly correlated phenotype, since it detected dedifferentiated hepatoma cell lines express neither nor starts before that during rat development, strongly increased upon retinoic acid induced differentiation F9 embryonic carcinoma cells. expressed epithelial component many organs endodermal mesodermal origin, suggesting they may play more general role associated specialized epithelia.