Two phases of replacement replenish the olfactory ensheathing cell population after injury in postnatal mice.

摘要: Olfactory ensheathing cells (OECs) support the regeneration of olfactory sensory neurons throughout life, however, it remains unclear how OECs respond to a major injury. We have examined proliferation and migration following unilateral bulbectomy in postnatal mice. S100s-DsRed OMP-ZsGreen transgenic mice were used visualize neurons, respectively, we thymidine analogue ethynyl deoxyuridine (EdU) identify that proliferating at time administration. Following bulbectomy, there was an initial phase OEC pathway with peak occurring 2 7 days after A second also occurred which precursors localized within mucosa divided replenish population. then tracked positions had proliferated found progressive increase cavity for least 12 16 injury could not be accounted solely by local cavity. These results suggest migrated from peripheral nerve populate mass filled left bulbectomy. Our demonstrate nervous system, population is replenished arise both as well precursor mucosa.