Transplantation of olfactory ensheathing cells in spinal cord injury

摘要: Spinal cord injury is characterized by massive cellular and axonal loss, a neurotoxic environment, inhibitory molecules physical barriers that hamper nerve regeneration reconnection leading to chronic paralysis. Transplantation of different types cells one the strategies being examined in order restore lost cell populations re-establish permissive environment for regeneration. The mammalian olfactory system few zones body where neurogenesis occurs during lifetime organism, with neurons replaced daily their axons elongating from peripheral nervous into central functional connections. regenerative ability this largely attributed presence unique group called ensheathing (OECs). OECs have emerged as an encouraging candidate transplantation therapies repair injured spinal multiple animal models showing significant improvements several human trials establishing procedure safe feasible. Even though results are promising some remarkable restoration function, variability amongst studies terms outcome assessments, purity, culture protocols make it difficult reach firm conclusions about effectiveness OEC transplant therapy treat cord. These variations need be addressed achieve more realistic understanding how benefits enhance therapeutic outcomes.