New antiarrhythmic agents for atrial fibrillation and atrial flutter.

摘要: Atrial fibrillation is the most common sustained cardiac arrhythmia and a frequent reason for antiarrhythmic therapy. Existing drugs have important side effects presently therapy to maintain sinus rhythm not superior strategy of controlling excessive heart rate. This review summarises current strategies improve atrial fibrillation. The are: i) develop without proarrhythmic – development devoid QT prolonging potential main strategy; ii) multiple channel-blocking inspired by efficacy amiodarone, several are being developed that similar electrophysiological properties as but extracardiac effects; iii) act exclusively in atria contain specific potassium channels, only on these channels development; iv) ion inhibitio...