Social dominance-related major urinary proteins and the regulatory mechanism in mice.
作者： Huifen GUO , Qi FANG , Ying HUO , Yaohua ZHANG , Jianxu ZHANG
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摘要: Major urinary proteins (MUPs) have been proven to be non-volatile male pheromones in mice. Here, we aimed elucidate the relationship between MUPs and dominance hierarchy, underlying molecular mechanisms. Dominance-submission was established by chronic dyadic encountering. We found that at protein level hepatic mRNA level, expression of major MUPs, including Mup20, enhanced dominant males compared with subordinate males, indicating might signal social status Meanwhile, corticotropin releasing hormone receptor 2 (CRHR2) higher mice than Castration also CRHR2, but suppressed MUPs. CRHR2 agonist treatment reduced liver. However, failed exert significant influence on serum testosterone corticosterone as well their receptors. These findings reveal some especially constitute potential could downregulated which is possibly independent androgen or systems.
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