The circadian rest-activity rhythm, a potential safety pharmacology endpoint of cancer chemotherapy.
作者： Elisabet Ortiz-Tudela , Ida Iurisci , Jacques Beau , Abdoulaye Karaboue , Thierry Moreau
DOI: 10.1002/IJC.28587
关键词:
摘要: The robustness of the circadian timing system (CTS) was correlated to quality life and predicted for improved survival in cancer patients. However, chemotherapy disrupted CTS according dose mice. A continuous repeated measures longitudinal design implemented here characterize dynamics patients receiving a fixed circadian-based protocol. rest-activity rhythm 49 with advanced monitored using wrist actigraph 13 days split into four consecutive spans 3-4 each, i.e., before, during, right after late chronotherapy course. relative amount activity bed vs. out (I
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