Role of Protease-activated Receptor-2 in Idiopathic Pulmonary Fibrosis
作者： Ewa Jablonska , Susanne von Gerlach , Ingrid Henneke , Dariusz Zakrzewicz , Andreas Guenther
DOI: 10.1164/RCCM.201009-1479OC
关键词:
摘要: Rationale: Activation of the coagulation cascade has been demonstrated in pulmonary fibrosis. In addition to its procoagulant function, various proteases exhibit cellular effects that may also contribute fibrotic processes lung.Objective: To investigate importance protease-activated receptor (PAR)-2 and activators, factor VIIa (FVIIa)/tissue (TF), development idiopathic fibrosis (IPF).Methods: Expression localization PAR-2 activators were examined IPF lung tissue. The ability mediate was studied vitro.Measurements Main Results: strongly elevated lungs attributable alveolar type II cells fibroblasts/myofibroblasts. Transforming growth factor-β1, a key profibrotic cytokine, considerably enhanced expression human fibroblasts. FVIIa stimulated proliferation fibroblasts extracellular matrix productio...
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