PAR‑2, IL‑4R, TGF‑β and TNF‑α in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis
作者： RADOSLAV MATĚJ , MAGDALENA SMĚTÁKOVÁ , MARTINA VAŠÁKOVÁ , JANA NOVÁKOVÁ , MARTINA ŠTERCLOVÁ
关键词:
摘要: Sarcoidosis (SARC) and extrinsic allergic alveolitis (EAA) share certain markers, making a differential diagnosis difficult even with histopathological investigation. In lung tissue, proteinase-activated receptor-2 (PAR-2) is primarily investigated regard to epithelial inflammatory perspectives. Varying levels of chemokines can be useful tool for distinguishing EAA SARC. Thus, in the present study, differences transforming growth factor (TGF)-β1, tumor necrosis (TNF)-α, interleukin-4 receptor (IL-4R) PAR-2 bronchoalveolar lavage fluid (BALF) were compared, using an ELISA method, between 14 patients six Statistically significant higher IL-4R, PAR-2/TGF-β1 PAR-2/TNF-α ratios observed as compared SARC patients. Furthermore, TNF-α/total protein, TGF-β1/PAR-2 TNF-α/PAR-2 significantly lower than The results indicated detection samples association TNF-α TGF-β levels. As parallel belong Th2-mediated pathway, this etiology. addition, that predominantly granulomatous disease, thus, are observed. Therefore, BALF may serve
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