Aggressive angiomyxoma: A clinicopathologic study of 29 female patients

摘要: BACKGROUND Aggressive angiomyxoma is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. Since its initial description in 1983, approximately 65 cases have been reported English literature. METHODS The clinical pathologic features 29 aggressive were evaluated a review archival material from Armed Forces Institute Pathology (1960–1992). Histochemical stains for mucosubstances immunohistochemistry (avidin-biotin complex method) utilized to characterize neoplasms further. RESULTS All patients females, between 16 70 years (median; 34 years). The soft tissues pelvis, perineum, vulva, buttock, retroperitoneum, inguinal involved. majority tumors were; ce10 centimeters greatest dimension. Follow-up ranging 8 198 months (mean, 93 months; median, 95 months) was available 22 patients. Eight developed recurrent tumor, 10 7 after resection. No patient metastases there no related deaths. Histologically, sparsely moderately cellular predominantly composed bland, relatively nondescript, stellate spindled cells embedded loosely collagenized matrix with scattered vessels varied caliber. A few contained some more abundant eosinophilic cytoplasm raised possibility focal smooth muscle differentiation. than weakly reactive mucosubstances; thus, while glycosaminoglycans are present limited extent, edema fluid appears be major component noncollagenous stroma. neoplastic at least focally immunoreactive desmin (22/22), actin (19/20), specific (16/19), vimentin (17/17), CD34/QBEND-10 (8/16), estrogen (13/14) progesterone (9/10) receptor. All examined negative S100 protein (20/20). Ki67 (MIB1) immunoreactivity <1% nuclei all tested. CONCLUSIONS Aggressive distinctive, locally aggressive, site has peak incidence females fourth decade life. There strong propensity local recurrence but metastatic disease not reported. first evidence may many resection, long term follow-up required. exhibit fibroblastic myofibroblastic appear hormonally influenced. progenitor cell capacity differentiation raised. Cancer 1996;78:79-90.