Hyperphosphatemia as an independent risk factor for coronary artery calcification progression in peritoneal dialysis patients

摘要: Background: Coronary artery calcification (CAC) is associated with cardiovascular mortality in end-stage renal disease (ESRD) patients. The present study aimed to identify modifiable risk factors for CAC progression peritoneal dialysis (PD) Methods: Adult patients who received regular PD more than 6 months and underwent a series of coronary score (CaCS) measurements by multislice spiral computed tomography (MSCT) an interval ≥ were included this observational cohort study. demographic characteristics clinical data, including laboratory data adequacy PD, collected. Curve estimation was used fit the straight line obtain slope. Binary logistic regression performed independent patients, multivariate linear conducted hyperphosphatemia. Results: A total 207 adult on (116 men, 56.0 %) mean age 59.8±15.9 years recruited study, 157 them (75.8 three or CaCS assessments. divided into slow group (n=137) rapid (n=70) according slope average speed development. follow-up time 33.0±18.8 months. Multivariate revealed that serum phosphate level after adjustments. hyperphosphatemia elevations transferrin albumin levels normalized protein catabolic rate (nPCR) reductions hemoglobin level, residual Ccr, Ccr. Conclusions: Hyperphosphatemia factor progression, may be intake adequacy. These results provide important information management ESRD