Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients.

作者: Ronney S. Shantouf , Matthew J. Budoff , Naser Ahmadi , Arshia Ghaffari , Ferdinand Flores

DOI: 10.1159/000294405

关键词:

摘要: Many traditional and nontraditional risk factors contribute to vascular calcification among maintenance hemodialysis (MHD) patients. It is not clear whether coronary artery (CAC) delineates a higher mortality independent of known factors. We examined 6-year (10/2001–9/2007) survival 166 MHD patients, aged 53 ± 13 years, with baseline CAC scores. Patients were grouped into four groups: 0, 1–100, 101–400, 400+. The 101–400 400+ groups associated significantly adjusted death than 0 hazard ratios (HR) 8.5 (95% CI: 1.1–48.1, p = 0.02) 13.3 1.3–65.1, 0.01), respectively, demographics, comorbidity, lipids other cardiovascular risks, surrogates bone disease, nutritional inflammatory markers dialysis dose. Total [HR 6.7 (1.1–21.5, 0.03)] followed by the presence in left main [4.6 (2.2–9.8, 0.001)] anterior descending [4.3 (2.1–14.2, strong predictors even after adjusting for above covariates. vessel-specific predict patients

参考文章(25)
Matthew J. Budoff, Leslee J. Shaw, Sandy T. Liu, Steven R. Weinstein, Philip H. Tseng, Ferdinand R. Flores, Tracy Q. Callister, Paolo Raggi, Daniel S. Berman, Tristen P. Mosler, Long-Term Prognosis Associated With Coronary Calcification: Observations From a Registry of 25,253 Patients Journal of the American College of Cardiology. ,vol. 49, pp. 1860- 1870 ,(2007) , 10.1016/J.JACC.2006.10.079
Robert Detrano, Alan D. Guerci, J. Jeffrey Carr, Diane E. Bild, Gregory Burke, Aaron R. Folsom, Kiang Liu, Steven Shea, Moyses Szklo, David A. Bluemke, Daniel H. O'Leary, Russell Tracy, Karol Watson, Nathan D. Wong, Richard A. Kronmal, Coronary calcium as a predictor of coronary events in four racial or ethnic groups. The New England Journal of Medicine. ,vol. 358, pp. 1336- 1345 ,(2008) , 10.1056/NEJMOA072100
Kamyar Kalantar-Zadeh, Charles J McAllister, Robert S Lehn, Grace H Lee, Allen R Nissenson, Joel D Kopple, Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients. American Journal of Kidney Diseases. ,vol. 42, pp. 761- 773 ,(2003) , 10.1016/S0272-6386(03)00915-6
Fadi G. Hage, Rajesh Venkataraman, Gilbert J. Zoghbi, Gilbert J. Perry, Angelo M. DeMattos, Ami E. Iskandrian, The Scope of Coronary Heart Disease in Patients With Chronic Kidney Disease Journal of the American College of Cardiology. ,vol. 53, pp. 2129- 2140 ,(2009) , 10.1016/J.JACC.2009.02.047
Kamyar Kalantar-Zadeh, T.Alp Ikizler, Gladys Block, Morrel M. Avram, Joel D. Kopple, Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. American Journal of Kidney Diseases. ,vol. 42, pp. 864- 881 ,(2003) , 10.1016/J.AJKD.2003.07.016
G.A. Block, P. Raggi, A. Bellasi, L. Kooienga, D.M. Spiegel, Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients. Kidney International. ,vol. 71, pp. 438- 441 ,(2007) , 10.1038/SJ.KI.5002059
Eric W. Young, Mineral Metabolism and Mortality in Patients with Chronic Kidney Disease Advances in Chronic Kidney Disease. ,vol. 14, pp. 13- 21 ,(2007) , 10.1053/J.ACKD.2006.10.003
RN Foley, PS Parfrey, MJ Sarnak, Clinical epidemiology of cardiovascular disease in chronic renal disease. American Journal of Kidney Diseases. ,vol. 32, ,(1998) , 10.1053/AJKD.1998.V32.PM9820470
GA Block, TE Hulbert-Shearon, NW Levin, FK Port, Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study American Journal of Kidney Diseases. ,vol. 31, pp. 607- 617 ,(1998) , 10.1053/AJKD.1998.V31.PM9531176
Paul M Ridker, Nader Rifai, Lynda Rose, Julie E Buring, Nancy R Cook, None, Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events The New England Journal of Medicine. ,vol. 347, pp. 1557- 1565 ,(2002) , 10.1056/NEJMOA021993