Maternal dietary resistant starch does not improve piglet's gut and liver metabolism when challenged with a high fat diet

摘要: In the past several years, use of resistant starch (RS) as prebiotic has extensively been studied in pigs, and this mostly critical period around weaning. RS is believed to exert beneficial effects on gastrointestinal tract mainly due higher levels short chain fatty acids (SCFAs) an improved microbiota profile. study, sows were fed digestible (DS) or during late gestation lactation possible maternal effect overall health progeny was assessed. Since also described have a positive metabolism, investigate metabolic programming progeny, half piglets per diet assigned high fat from weaning 10 weeks after. No bodyweight differences found between four experimental piglet groups. The did however impact back thickness meat percentage whereas not influence these parameters. reflected serum cholesterol. major could be distinguished, although SCFA seen colon born sows, some production observed caecum, diet. RNA-sequencing liver scrapings revealed minor Merely handful genes differentially expressed DS network analysis showed only one significant cluster that point meaningful biological pathways. However, resulted gene clusters significantly correlated with diet, which annotated for lipid processes. These There dietary changes. A given directly evokes changes liver, without any by