Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22
作者： Linda M Brzustowicz , Kathleen A Hodgkinson , Eva WC Chow , William G Honer , Anne S Bassett
DOI: 10.1126/SCIENCE.288.5466.678
关键词:
摘要: Schizophrenia is a complex disorder, and there substantial evidence supporting genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia in 22 extended families with high rates of provided highly significant linkage chromosome 1 (1q21-q22), maximum heterogeneity logarithm the likelihood (lod) score 6.50. This result should provide sufficient power allow positional cloning underlying gene.
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