Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT.
作者： J Nakano , C Huang , D Liu , D Masuya , T Nakashima
关键词:
摘要: The sensitivity to 5-fluorouracil (5-FU) has been reported be associated with target molecule thymidylate synthase (TS), fluoropyrimidine-metabolising enzymes such as orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD). We performed an immunohistochemical study on the clinical significance of TS, OPRT, DPD expression using 151 resected non-small-cell lung cancer (NSCLC) patients postoperatively treated a combination tegafur uracil (UFT). Eighty-two carcinomas were TS-positive, 105 OPRT-positive, 68 DPD-positive. No correlation was observed in HSCORE between TS OPRT (r=0.203), (r=0.098), or (r=0.074). Regarding survival NSCLC UFT, 5-year rate TS-negative tumours significantly higher than that TS-positive (P=0.0133). OPRT-positive stage II III OPRT-negative (P=0.0145). In addition, DPD-negative also DPD-positive (P=0.0004). A Cox multivariate regression analysis revealed status (hazard ratio 2.663; P=0.0003), 2.543; P=0.0005), 2.840; P<0.0001) all significant prognostic factors for UFT.
nature.com
sci-hub.se 参考文章(55)
Zenro Nihei, Hiroyuki Uetake, Hiroyuki Yamada, Yoshinori Shirota, Kenichi Sugihara, Naoto Nishi, Wataru Ichikawa, Renzo Hirayama, Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clinical Cancer Research. ,vol. 9, pp. 786- 791 ,(2003)
Leight Gs, Flowers Jl, Soper Jt, McCarty Ks, Cox Eb, Konrath J, Miller L, Creasman Wt, Budwit Da, Szabo E, Use of a Monoclonal Anti-Estrogen Receptor Antibody in the Immunohistochemical Evaluation of Human Tumors Cancer Research. ,vol. 46, ,(1986)
L.G. Navalgund, C. Rossana, A.J. Muench, L.F. Johnson, Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts. Journal of Biological Chemistry. ,vol. 255, pp. 7386- 7390 ,(1980) , 10.1016/S0021-9258(20)79715-2
Akiko Sadata, Yasushi Shiratori, Masao Omata, Keisuke Tateishi, Fumihiko Kanai, Torao Tanaka, Makoto Ohashi, Takayuki Kawakami, Hirofumi Hamada, Yoko Yoshida, Adenovirus-mediated Transduction of Escherichia coli Uracil Phosphoribosyltransferase Gene Sensitizes Cancer Cells to Low Concentrations of 5-Fluorouracil Cancer Research. ,vol. 58, pp. 1946- 1951 ,(1998)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
H J Lenz, C G Leichman, K D Danenberg, P V Danenberg, S Groshen, H Cohen, L Laine, P Crookes, H Silberman, J Baranda, Y Garcia, J Li, L Leichman, Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. Journal of Clinical Oncology. ,vol. 14, pp. 176- 182 ,(1996) , 10.1200/JCO.1996.14.1.176
Y M Rustum, A Harstrick, S Cao, U Vanhoefer, M B Yin, H Wilke, S Seeber, Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors. Journal of Clinical Oncology. ,vol. 15, pp. 389- 400 ,(1997) , 10.1200/JCO.1997.15.1.389
H Wada, S Hitomi, T Teramatsu, Adjuvant chemotherapy after complete resection in non-small-cell lung cancer. West Japan Study Group for Lung Cancer Surgery. Journal of Clinical Oncology. ,vol. 14, pp. 1048- 1054 ,(1996) , 10.1200/JCO.1996.14.4.1048
H Takiuchi, J A Ajani, Uracil-tegafur in gastric carcinoma: a comprehensive review. Journal of Clinical Oncology. ,vol. 16, pp. 2877- 2885 ,(1998) , 10.1200/JCO.1998.16.8.2877
Patrick M. Rocco, Joseph G. Antkowiak, Hiroshi Takita, John D. Urschel, Long-term outcome after pneumonectomy for nonsmall cell lung cancer Journal of Surgical Oncology. ,vol. 61, pp. 278- 280 ,(1996) , 10.1002/(SICI)1096-9098(199604)61:4<278::AID-JSO9>3.0.CO;2-7